Frequently Asked Questions
When is Tocilizumab used to treat Autoimmune Encephalitis?
Sometimes patients do not respond to Rituxan/Rituximab. This resistance to response is call ‘refractory’ to the treatment.
Tocilizumab is an available alternative treatments. Tocilizumab interrupts the inflammatory effects of a molecule called interleukin-6 (IL-6). Normally, when IL-6 binds to its receptors on immune
cells, it causes B cells to multiply and mature into antibody-producing cells, and causes proinflammatory T cells to mature. The antibody drug tocilizumab targets the IL-6 receptor and prevents these inflammatory processes. A molecule related to IL-6, IL-2, is also a target. Instead of inhibiting this molecule, giving patients low doses of IL-2 activates a “good” type of T
cell called regulatory T cells that help the body shut down autoimmune responses.
Recommended study for further information: