APRIL NEWSLETTER
HIGHLIGHTED NEWS IN AUTOIMMUNE ENCEPHALITIS
As April has Showered us with News, enjoy the
1st April installment of THE HERD.
Meet a remarkable artist whose explains how her AE inspired art has helped her process all the emotions and complexities of having anti-NMDAr AE and given her a sense of purpose.
3 important papers about Limbic Encephalitis covering Genetic predisposition, Misdiagnosis with anti-LGI1 limbic encephalitis when Initial psychiatric symptoms mislead clinicians and Antibody‐negative Limbic Encephalitis. Plus 2 more highlighted articles.
Meet Artist Julia King~ whose Art is all a ‘Dazzel’
Everyone knows a group of lions is called a pride. What you may not know is a group of zebras is called a ‘Dazzel’.
Julia has been drawing and creating art since she was a young child. She says her zebras and AE inspired art has really helped her process all the emotions and complexities of her illness and given her a sense of purpose. Diagnosed with anti-NMDAr autoimmune encephalitis in 2016, the illness has cost her 3 jobs, and almost all of her self-confidence she confides. “But the zebras have given me some of my happiness back.”, she says with a smile.
If you are looking for just the right zebra gift for that AE Warrior in your life, go on safari through Julia’s dazzel. 10% of her proceeds are donated to supporting IAES’ mission.
Psychiatric symptoms delay the diagnosis of anti-LGI1 encephalitis
This is the first study to analyze the detailed profiles and prognostic implication of the psychiatric symptoms in patients with anti-LGI1 encephalitis.
1.
Of 16 patients, more than a half of the patients (10, 62.5%) presented psychiatric symptoms as the initial manifestation of the encephalitis.
2.
The presence of initial psychiatric symptoms delayed the time to the first-line immune therapy, affecting the subacute and final outcome of the patients.
3.
Initial manifestation of psychiatric symptoms in patients with anti-LGI1 encephalitis is a poor prognostic factor, misleading both the patients and the clinicians.
Open Access Link
To James Scott’s excellent paper, The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis: screening acutely unwell people with psychosis for neuronal antibodies identified 4 NMDAR antibody positive cases w/ clear CNS inflammation whose psychosis remitted w/ immunotherapy.
Despite the discovery of new antibodies, 7% of Limbic Encephalitis remains seronegative. Antibody‐negative LE is more frequent in older males and usually develops with predominant or isolated short‐term memory loss. Despite the absence of antibodies, patients may have an underlying cancer and respond to immunotherapy.
Original Article
Syndrome and outcome of antibody‐negative limbic encephalitis
~ Other important April Publications ~
Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis
Clinical and pathogenic significance of IgG, IgA, and IgM antibodies against the NMDA receptor
International Autoimmune Encephalitis Society (IAES) is a Family/Patient centered organization that assists members from getting a diagnosis through to recovery and the many challenges experienced in their journey.
Driven by the knowledge that “Education is Power”, Int’l AE Society manages an educational support group for patients diagnosed with Autoimmune Encephalitis and their loved ones on Face Book, empowering them to be strong self-advocates and advocates that will lead them to best outcomes and recovery. We are the premiere organization leading in these vital roles.
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