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THE HERD March 2018

image 6 1 - THE HERD March 2018



This issue focuses on anti-NMDAr encephalitis. There has been a recent explosion of studies of serum and CSF biomarkers in NMDAR encephalitis that claim to predict outcome.  If you have a diagnosis of anti-NMDAr encephalitis, we recommend you provide your neurologist with these studies in the event they have not seen them. Also included is a case study that identifies another infection that may trigger anti-NMDAr.

anti-NMDAr encephalitis Study

New Correlations to Outcomes

Highlights from this study showed significant increases in CSF PTX3, CD40L, IL-6, and IL-17A in anti-NMDAR encephalitis patients. •CSF PTX3 positively correlated with IL-6 and Modified Ranking Scale (mRS). CSF CD40L positively correlated with IL-17A and mRS in these patients.

anti-NMDAr encephalitis

CSF NSE and S100B concentration in patients with anti-NMDAR encephalitis is higher than in patients with non-inflammatory neurological disease. The early NSE or S100B concentrations in CSF were associated with theModified Ranking Scale (mRS) and we can use it to determine the prognosis of the disease. 

3rd study on anti-NMDAr this month that discusses insights into outcomes

Our results show that the serum levels of CysC are associated with anti-NMDAR encephalitis and its clinical parameters and that the changes in CysC levels correlate with therapeutic effect. Therefore, our findings provide new insights into the association between serum CysC and anti-NMDAR encephalitis.

New case study just out moves us another step ahead in identifying another infection that may trigger anti-NMDAr. This is the exact type of research we watch and hope for as researchers hunt down answers that we hope will one day lead to prevention.

International Autoimmune Encephalitis Society (IAES) is a Family/Patient centered organization that assists members from getting a diagnosis through to recovery and the many challenges experienced in their journey. 


Driven by the knowledge that “Education is Power”, Int’l AE Society manages an educational support group for patients diagnosed with Autoimmune Encephalitis and their loved ones on Face Book, empowering them to be strong self-advocates and advocates that will lead them to best outcomes and recovery. We are the premiere organization leading in these vital roles.

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