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Selected Highlighted News in the field of Autoimmune
Encephalitis September 2019 1st edition
In this Issue~
- IAES turns 3: Become an IAES Angel
- Most Popular Article of the Month: Music Therapy of brain injury
- Most Popular Video of the Month: Chelsea Chisholm’s presentation of her own experience with anti-NMDAr encephalitis
- STUDY Needs Your Participation: Understanding Consequences of Encephalitis
- Most Shared Post: Symptoms in AE
- Clinician’s Corner: Comparison between auto-antibody negative and auto-antibody positive Autoimmune Encephalitis patients
- Open Access: CFS findings in Patients with Autoimmune Encpehalitis- A systematic Analysis
When you become an #IAESANGEL, International Autoimmune Encephalitis Society will send you this badge and profile frame to place on your Facebook page or Website. As badges ‘take flight’ heralding IAES has been ‘touched by an angel’, others will take notice and they too may find their wings. Together, we will create a future where AE is eradicated from this world and only referenced in medical history books.
Most Popular Article of the Month~
Doctors Now Prescribing Music Therapy for Brain Dysfunction, Learning Disabilities, Depression, PTSD, Alzheimers and More
Though traditional “music therapy” encompasses a specific set of practices, the broader use of music as a therapeutic tool can be seen nowadays as doctors are found recommending music for a wide variety of conditions. When it comes to the human brain, music is one of the best medicines.
Most Popular Video of the Month~
In our Feature: *Throw Back Thursday* On September 5th,
IAES threw you back to Feb 28, 2013. Your response gave this video a standing ovation!
If you are recently diagnosed or have had a diagnosis for a while – this is a ‘must watch’ video!
Gather Family & Friends and have the popcorn ready. This is a 2 hour presentation will keep your attention and will have you learning more than you could have imagined watching Chelsea take you through her harrowing experience with anti-NMDAr encephalitis.
Chelsea Chisholm, as a nursing student, presented her personal case history of Anti-NMDA Receptor Encephalitis. She warns that health care members need to be more aware of this condition, as a misdiagnosis can be fatal to the patient.
Most Liked and Shared IAES Post
Symptoms in Autoimmune Encephalitis
Clinical, radiological and laboratory comparison between autoantibody-negative and autoantibody-positive Autoimmune Encephalitis patients.
Recognition of AE is important because patients may benefit from several lines of immunomodulatory treatment, which is more effective as soon as it is started.
This research looked at 18 patients with identified antibodies in AE and 14 who were antibody negative. They did not find any significant differences between the two groups.
Conclusions: AE-patients show similar features if compared to AE+ patients, except for autoantibody detection. As outlined by recent guidelines, our work suggests that, if clinical picture is highly suggestive for AE, antibody detection is not mandatory for diagnosis and, therefore, immunomodulatory treatment must not be delayed.
Cerebrospinal Fluid Findings in Patients With Autoimmune Encephalitis-A Systematic Analysis
The authors systematically reviewed the literature about the 10 most important AE subtypes, AE with antibodies against NMDA, AMPA, glycine, GABAA , and GABAB receptors as well as DPPX, CASPR2, LGI1, IgLON5, or glutamate decarboxylase (GAD), with respect to the reported basic CSF findings comprising CSF leukocyte count, total protein, and the presence of oligoclonal bands (OCB) restricted to the CSF as a sensitive measure for intrathecal IgG synthesis.
Our results indicate that these basic CSF findings are profoundly different among the 10 different AE subtypes. Whereas, AEs with antibodies against NMDA, GABAB , and AMPA receptors as well as DPPX show rather frequent inflammatory CSF changes, in AEs with either CASPR2, LGI1, GABAA , or glycine receptor antibodies CSF findings were mostly normal. Two subtypes, AEs defined by either GAD, or IgLON5 antibodies, did not fit into this general pattern. In AE with GAD antibodies, positive OCBs in the absence of other changes were typical, while the CSF in IgLON5 antibody-positive AE was characterized by elevated protein.
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International Autoimmune Encephalitis Society (IAES) is a Family/Patient centered organization that assists members from getting a diagnosis through to recovery and the many challenges experienced in their journey.
Driven by the knowledge that “Education is Power”, Int’l AE Society manages an educational support group for patients diagnosed with Autoimmune Encephalitis and their loved ones on Face Book, empowering them to be strong self-advocates and advocates that will lead them to best outcomes and recovery. We are the premiere organization leading in these vital roles.